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UID:1211@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240306T130000

DTEND;TZID=Asia/Jerusalem:20240306T133000

DTSTAMP:20240222T074750Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-mallik
 -monalisha/

SUMMARY:Msc Graduate Seminar-Monalisha Mallik [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/94790301143  Mallik Monalisha\n Affiliation: \n Host: 	Prof.
  Arava Yoav\n Role of Amino-acyl tRNA synthetases in the regulation of tra
 nslation of mRNAs encoding for enzymes in amino acid biosynthesis pathways
 \nAmino-acyl tRNA synthetases are enzymes that catalyse the aminoacylation
  reaction\, where an amino acid is covalently linked to its cognate tRNA. 
 Besides this canonical function of tRNA aminoacylation\, aaRSs have a role
  in several metabolic and signalling pathways. A role in post-transcriptio
 nal regulation is known through binding to mRNA. Recent RIP-seq results fr
 om our lab revealed mRNA repertoire bound by many yeast aaRS. Interestingl
 y many mRNAs encoding proteins involved in amino acid biosynthesis and rib
 osome biogenesis were detected. This implies that aaRS might induce regula
 tion on these biological functions via the mRNA binding. The role of aaRS 
 in amino acid biosynthesis and the mechanism of this regulation is explore
 d in this project. To achieve this\, we perform amino acid starvation expe
 riments to study how starvation causes alteration in the expression of the
  mRNAs and their binding to aaRS. Further\, we study whether this alterati
 on is due to a translation regulatory impact of the bound aaRS. Most impor
 tantly\, as the mRNAs bound by aaRS show\nenrichment of tRNA anticodon-lik
 e structures\, we are also checking the impact of tRNA overexpression on t
 he binding of mRNAs. This work uncovers new mechanisms of translation cont
 rol by aaRSs\, and the role of tRNA-like sequences in this process.\n 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /94790301143

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