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UID:1207@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240214T133000

DTEND;TZID=Asia/Jerusalem:20240214T140000

DTSTAMP:20240130T111758Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-maram-
 halabi/

SUMMARY:Msc Graduate Seminar- Maram Halabi [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/94568387345  Maram Halabi\n Affiliation: \n Host: Prof. Arav
 a Yoav\n Impact of pseudouridylation on mitochondrial tRNA recognition by 
 cognate synthetase\n\n\n\nMitochondrial tRNAs (mt-tRNAs) undergo an extens
 ive post-transcriptional modification. One such common modification is pse
 udouridylation\, the conversion of uridine to a 5’-ribosyl isomer of uri
 dine. Although it is the most abundant modified nucleoside to be known in 
 RNA\, in most cases the contribution of this modification to the translati
 on process is not clear. Previous research conducted\, by Levi O and Arava
  YS\, in our lab has shown that pseudouridine in cytosolic tRNA affects th
 e regulation of translation. Specifically\, the deletion of Pus6 resulted 
 in a reduction of MetRS binding to tRNAMet. Yet no studies have been condu
 cted to test this on mt-tRNAs. Here we analyzed this impact by removal of 
 specific pseudouridine enzymes that worked on several mt-tRNAs (tRNAArg\, 
 tRNALys\, tRNASer). We generated yeast strains deleted of these enzymes: P
 us2\, Pus4\, Pus6\, or Pus9. We tested the in vivo impact on the binding o
 f each tRNA to its cognate aminoacyl tRNA synthetase (aaRS). Our results s
 how that Pus4 plays a role in the SerRS binding tRNASer and tRNALys\, Pus6
  deletion impacts the LysRS binding to tRNASer\, and Pus4 deletion impacts
  the binding of ArgRS to non-cognate tRNAs. This study presents the first 
 in vivo characterization of pseudouridylation impact on mt-tRNA binding to
  cognate mt-aaRS\, shedding new light on the role of this modification in 
 mitochondrial translation regulation. 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /94568387345

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