BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.2.1//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1198@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230905T133000 DTEND;TZID=Asia/Jerusalem:20230905T140000 DTSTAMP:20230903T094317Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-miryam -steinberg/ SUMMARY:Msc Graduate Seminar-Miryam Steinberg [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/97039787933 Miryam Steinberg\n Affiliation: \n Host:Associ ate Prof. David Meiri\n CBDV modulates myeloid suppressor cells in the tum or microenvironment\n \;\n\nDuring solid tumor progression\, the tumor microenvironment (TME) evolves into a highly immunosuppressive milieu. Ke y players in the immunosuppressive environment are regulatory myeloid cell s\, including myeloid-derived suppressor cells (MDSCs) and tumor-associate d macrophages (TAMs). Therefore\, the modulation of immunosuppressive cell s in the TME to create a more active environment is a compelling strategy for preventing tumor progression. Here\, we found that Cannabidivarin (CBD V)\, a minor cannabinoid\, directly reduces the immunosuppressive properti es of MDSCs and shifted their differentiation from TAMs to M1-like macroph ages. Treating myeloid suppressor cells with CBDV led to restored CD8+ T-c ell activation and proliferation in a co-culture model. Tumor-bearing mice treated with CBDV presented reduced tumor progression\, and myeloid suppr essor cells in the TME showed a reduction in immunosuppressive markers\, i n line with enhancing CD8+ T-cell activity. CBDV was also effective in hum an cells\, reducing immunosuppressive markers by human myeloid suppressor cells. Altogether\, our findings indicate CBDV holds the potential to repr ogram immune system cells within the TME to strengthen the immune response against cancer.\n\n \; LOCATION: Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/97039787933 END:VEVENT BEGIN:VTIMEZONE TZID:Asia/Jerusalem X-LIC-LOCATION:Asia/Jerusalem BEGIN:DAYLIGHT DTSTART:20230324T030000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:IDT END:DAYLIGHT END:VTIMEZONE END:VCALENDAR