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UID:1307@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250908T133000

DTEND;TZID=Asia/Jerusalem:20250908T140000

DTSTAMP:20250907T065924Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-netane
 l-amiel/

SUMMARY:MSc Graduate Seminar-Netanel Amiel [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/95534105252  Netanel Amiel\n Affiliation: \n Host:Associat
 e Prof. David Meiri  \n The cumulative effect of cannabinoids on the immun
 e system in IBD mouse models\n\n&nbsp\;\n\nInflammatory bowel disease (IBD
 ) is a chronic\, relapsing inflammatory disorder of the gastrointestinal t
 ract\, and current therapies often rely on immunosuppression with limited 
 long-term success. To explore alternative strategies\, we examined the pot
 ential of cannabinoids to modulate both adaptive and innate immune pathway
 s relevant to IBD. Previous work in our lab showed that cannabidiolic acid
  (CBDA) affected the adaptive immune system by reducing pro-inflammatory T
  cell responses\, while a combination of cannabidiol (CBD) and cannabidiva
 rin (CBDV) acted on innate immunity by limiting CXCR4-dependent recruitmen
 t of inflammatory cells to the gut. We hypothesized that combining these c
 ompounds might provide additive or synergistic benefits by targeting compl
 ementary arms of the immune system. Using both acute and chronic DSS-induc
 ed colitis models in mice\, we assessed disease severity under separate an
 d combined treatments. While each treatment effectively reduced disease se
 verity\, the combination did not yield additive effects\, pointing the nee
 d for further exploration of cannabinoids in gut inflammation 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/95534105252

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