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UID:1116@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220809T130000

DTEND;TZID=Asia/Jerusalem:20220809T133000

DTSTAMP:20220818T115606Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-nitzan
 -goldberger/

SUMMARY:MSc Graduate Seminar-Nitzan Goldberger [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Research subject:\n\nThe
  role of caspase-9 in hairfollicle stem cells.\n\nSummary:\n\nProgramed ce
 ll death(PCD) serves many important functions in mammalian development and
  tissuehomeostasis. These include shaping tissue morphology during organog
 enesis and eliminatingaberrant cells within the adult organism. Given thei
 r capacity forself-renewal and differentiation into various cell types\, i
 t is unsurprisingthat stem cells (SCs) have been demonstrated to utilize P
 CD in the form ofapoptosis for maintenance of homeostasis and tissue repai
 r in the adultorganism. Recently\, new insights regarding the unique mecha
 nism that instructselimination of these cells have been found. In our rese
 arch\, we examine theapoptotic machinery in the hair follicle\, which hous
 es a multitude of distinct stemcell populations\, and how this in turn aff
 ects the environment. We foundthat deletion of Caspase-9 (Casp9) in hair f
 ollicle stemcells attenuates the apoptotic cascade\, resulting in signific
 ant temporaldelays that prevent cells from being rapidly cleared. As a res
 ult\, Casp9-deletedcells become mitogenic and secrete Wnt3 to the environm
 ent via acaspase-3/Dusp8/p38 pathway.\n\nThe seminar will be given inEngli
 sh 

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