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UID:969@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20210721T130000

DTEND;TZID=Asia/Jerusalem:20210721T140000

DTSTAMP:20210802T130802Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-noga-a
 harony-2/

SUMMARY:MSC Graduate seminar- Noga Aharony [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Whilemobile genetic elem
 ents play a consequential part in bacterial adaptation andantibiotic resis
 tance\, relatively little is known about their role inwithin-host pathogen
  evolution. To explore their function\, we constructed acomputational pipe
 line that identifies variations in gene content amongbacteria of the same 
 strain and applied it to a dataset of over a thousandisolates from recurri
 ng urinary tract infections. We discovered that aconsiderable number of pa
 thogens had variations in gene content upon theirrecurrence. The elements 
 belonged to diverse types\, including phage\,transposon\, or plasmid. Nota
 bly\, some of the mobile elements contained knownantibiotic resistance gen
 es and lead to an increase in the isolate'sresistance. We therefore conclu
 de that changes in gene content are common andrapid\, and may be functiona
 lly important for clinical outcomes of antibiotictreatment. 

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DTSTART:20210326T030000

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