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UID:1071@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220322T130000

DTEND;TZID=Asia/Jerusalem:20220322T133000

DTSTAMP:20220713T072649Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-oren-m
 ilman/

SUMMARY:MSc Graduate Seminar- Oren Milman [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Systematicidentification
  of gene-altering programmed inversions across the bacterialdomain Progra
 mmedchromosomal inversions allow bacteria to generate intra-population gen
 otypicand functional heterogeneity\, a bet-hedging strategy important in c
 hangingenvironmental challenges\, such as bacteriophages and antibiotic dr
 ugs. Someprogrammed inversions modify coding sequences\, producing differe
 nt alleles inseveral gene families\, most notably in specificity-determini
 ng genes such asphage-tail\, outer-membrane receptors and Type I restricti
 on-modificationsystems\, where systematic searches revealed cross phylum a
 bundance. Yet\, abroad systematic search for gene-altering programmed inve
 rsions\, not guided bypreviously known gene families\, has been absent\, a
 nd little is known abouttheir prevalence across gene families and their co
 mmon genomic architectures.Here\, scanning for intra-species variation in 
 genomes of over 35\,000 species\,we develop a predictive model of gene-alt
 ering inversions\, revealing keyattributes of their genomic architectures\
 , including recombinase-proximity andgene-pseudogene size asymmetry. The m
 odel predicted over 1200 gene-alteringloci covering known gene families as
  well as Type II restriction-modificationsystems previously not characteri
 zed for programmed inversions. Publiclyavailable long-read sequencing data
 sets validated representatives of recurringpredicted inversion-targeted ge
 ne families\, confirming intra-population geneticheterogeneity\, even with
  multiple co-existing combinatorial variants inmultiple inversion systems.
  Together\, these results reveal gene-alteringprogrammed inversions as a k
 ey strategy adopted across the bacterial domain\,and highlight inversions 
 of Type II restriction-modification systems as apossible new mechanism for
  maintaining intra-population heterogeneity. 

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