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UID:968@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20210720T130000

DTEND;TZID=Asia/Jerusalem:20210720T140000

DTSTAMP:20210802T125905Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-ran-ta
 han-2/

SUMMARY:MSC Graduate seminar-Ran Tahan [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Researchtopic: The dualr
 ole of a cyanophage thioredoxinAbstract:Marinecyanobacteria are highly abu
 ndant photosynthetic organisms that contributegreatly to global primary pr
 oduction. Their viruses\, marine cyanophages\, arealso extremely abundant 
 and have a major effect on cyanobacterial populations\,diversity and evolu
 tion. One abundant family of cyanophages\, the T7-likecyanopodoviruses can
  be divided into two major clades\, A and B\, which areclosely related but
  differ significantly in their infection dynamics\, as wellas in their abu
 ndance and distribution. Here\, we set out to test whether thethioredoxin 
 gene\, found only in clade A phages\, contributes to the differencesbetwee
 n the clades. We hypothesized that it is involved in phage DNAreplication 
 similar to the role of the host gene in the T7-E. colisystem. To test our 
 hypothesis\, we used a newly developed gene inactivationsystem to study th
 e thioredoxin gene\, trxA in the clade A phages Syn5.We found that the del
 etion of this gene caused a decline in phage DNAreplication. To our surpri
 se\, we also found that trxA expression inhibitsthe growth of the cyanobac
 terial host. Our work revealed how a non-essential host-acquiredgene contr
 ibutes in more than one way to cyanophage fitness. Furthermore\, ourresult
 s indicate that some of the physiological differences between the twoclade
 s of the T7-like cyanopodoviruses can be attributed to a clade-specific ge
 ne. 

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