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UID:1274@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250401T133000

DTEND;TZID=Asia/Jerusalem:20250401T140000

DTSTAMP:20250330T073904Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-rinat-
 indig/

SUMMARY:Msc Graduate Seminar-Rinat Indig [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/93635760084  Rinat Indig\n Affiliation: \n Host:Associate 
 Prof. Meytal Landau\n &nbsp\;\n\n Modulating Virulent Amyloids Via Nuclei
 c-Acid and Small Molecules\n\nProteins and peptides can aggregate into amy
 loid fibrils\, while their formation\, structure and function are influenc
 ed by environmental and biological factors. Amyloids have diverse roles in
  different organisms. In bacteria\, amyloids contribute to key characteris
 tics and processes\, such as virulence and biofilm formation\, that provid
 e a shield against immune responses and antibiotics. Two examples of such 
 bacteria are Staphylococcus aureus and Pseudomonas aeruginosa which secret
 e the amyloid proteins PSMα and Fap\, respectively. Our work revealed sev
 eral compounds that selectively inhibit these amyloids. Moreover\, we foun
 d that RNA and DNA significantly accelerated Fap fibrillation and broadene
 d the fibrillation conditions. Our findings advance the understanding of a
 myloid involvement and interactions within the biofilm\, opening the way f
 or developing therapeutic strategies against biofilm-forming bacteria. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/93635760084

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