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UID:1301@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250812T130000

DTEND;TZID=Asia/Jerusalem:20250812T133000

DTSTAMP:20250715T071927Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-shahar
 -lavid/

SUMMARY:MSc Graduate Seminar-Shahar Lavid [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/96544365611  Shahar Lavid\n Affiliation: \n Host:Prof. Ben
 jamin Podbilewicz \n  Title: Structure Prediction and Sequence Phylogeny 
 of Fusion Family (FF) Proteins Indicate a Common Ancestor in Nematodes and
  Horizontal Gene Transfer Origin in Non-Nematodes13\n\nThe fusexin superfa
 mily comprises proteins that mediate cell-cell fusion during viral infecti
 ons\, somatic development and sexual reproduction\, and have also been ide
 ntified in Archaea. Among them\, a subfamily of FF proteins\, first identi
 fied in the nematode C. elegans\, exhibits a striking structural similarit
 y to Class II viral fusogens. This similarity\, however\, is absent at the
  sequence level\, making their evolutionary origin difficult to pinpoint. 
 By analyzing the phylogenetic relationships and structural predictions of 
 FF candidate ectodomains\, we present a phylogenetic inquiry of FF protein
 s in both nematode and non-nematode species. Results show that nematodes h
 arbor two distinct FF subgroups\, which correspond to the C. elegans fusog
 ens EFF-1 and AFF-1 and align with nematode phylogeny. In contrast\, the g
 eneral phylogeny of FF in non-nematode species diverges from broader inver
 tebrate evolution. The results reveal the variable origins of FF proteins 
 and suggest divergence in their structural properties as well\n\n&nbsp\; 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/96544365611

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DTSTART:20250328T030000

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