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UID:1255@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20241211T130000

DTEND;TZID=Asia/Jerusalem:20241211T133000

DTSTAMP:20241201T104523Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-sharon
 -fitoussi/

SUMMARY:MSc Graduate Seminar- Sharon fitoussi [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:  https://tech
 nion.zoom.us/j/99669094452   Sharon Fitoussi\n Affiliation: \n Host: 	Prof
 . Podbilewicz Benjamin\n The understanding of pathological body wall muscl
 e cell fusion mediated by ectopic expression of the fusogen - EFF-1 in Cae
 norhabditis elegans.\n\n&nbsp\;\n\nAbstract:\n\nIn vertebrates\, skeletal 
 muscle develops through myoblast fusion\, forming a vast multinuclear stru
 cture\, while other muscles such as smooth muscles do not fuse. In Caeno
 rhabditis elegans\, body movement is coordinated through unfused body wall
  muscle (BWM) cells\, whereas other muscle tissues rely on cell fusion req
 uiring the fusion protein EFF-1. To study the role of cell fusion in muscl
 es\, we induced the ectopic expression of EFF-1 in BWMs. We found that thi
 s treatment induced cell merger and an uncoordinated dumpy morphology\, in
 dicating that cell fusion is detrimental for BWMs function. Using modified
  mosaic analysis\, we provide evidence that EFF-1 expression is required o
 n both fusing cells\, consistent with a bilateral and homotypic mechanism 
 of fusion. These findings expand our knowledge of the consequences of path
 ological muscle fusion\, with potential implications in different diseases
 . 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:  https://technion.zoom.us/
 j/99669094452

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