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UID:1165@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230328T130000

DTEND;TZID=Asia/Jerusalem:20230328T133000

DTSTAMP:20230308T082329Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-shiraz
 -schiller/

SUMMARY:MSc.  Graduate Seminar- Shiraz Schiller [No Categories]
DESCRIPTION:Location: Faculty Of Biology Auditorium: https://technion.zoom.
 us/j/93656461086   Shiraz Schiller\n Affiliation: \n Host:Associate Prof. 
 Meiri David\n Estrogen Receptor Modulation by a Newly-Identified Phytocann
 abinoid in a Preclinical Model of Breast Cancer\n\nBreast cancer is made u
 p of different subtypes that respond differently to treatments. Tumors tha
 t express estrogen receptor alpha (ERα) and depend on estrogen for propag
 ation constitute 60%-70% of all cases. They are commonly treated with endo
 crine therapy such as Selective Estrogen Receptor Modulators (SERMs)\, the
  best known of which is Tamoxifen. However\, despite its obvious benefits\
 , many patients that start Tamoxifen therapy do not complete the whole tim
 e-course because of adverse effects. Here\, we identified a novel phytocan
 nabinoid from whole extracts of Cannabis\, which we termed 373.15b\, that 
 was able to prime ER-positive tumors to the cytotoxic effect of tamoxifen 
 without any toxicity by itself. Thus\, allowing the use of significantly l
 ower doses while still achieving the same outcome. A similar effect of 373
 .15b was demonstrated in combination with other types of SERMs as well. 37
 3.15b affects estrogen signaling by decreasing the protein expression leve
 ls of ERα and its transcriptional activity. We show its mechanism of acti
 on involves the modulation of the Hippo signaling pathway. Our work sugges
 ts that co-therapy for ER-positive breast cancer patients with SERMs and 3
 73.15b can reduce the treatment dosage of the conventional therapy and by 
 that diminish the associated adverse effects and improve patient quality o
 f life.\n\n&nbsp\;\n\n&nbsp\; 
LOCATION:Faculty Of Biology Auditorium: https://technion.zoom.us/j/93656461
 086

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