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UID:1305@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250909T133000

DTEND;TZID=Asia/Jerusalem:20250909T140000

DTSTAMP:20250904T132848Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-tylor-
 brent-de-leon/

SUMMARY:MSc Graduate Seminar-Tylor-Tyler Brent de Leon [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM:  - https://
 technion.zoom.us/j/4885283424  Tylor-Brent De-Leon\n Affiliation: \n Host:
 Prof. Yoav Arava \n Locally synthesized glycyl aminoacyl tRNA synthetase (
 GARS1) is important for  local translation in neurons\n\nRegulation of ge
 ne expression is essential for neuronal development and function. A promin
 ent regulatory mechanism involves synthesis of proteins at their activity 
 site. Such local protein synthesis enables neurons to respond rapidly and 
 tightly to stimuli. Key components of the translation machinery\, includin
 g mRNA and ribosomes\, were identified in subcellular regions of neurons. 
 Yet\, the role of tRNAs and their charging enzymes\, aminoacyl tRNA synthe
 tases (aaRS)\, in this process remains largely unclear. Here\, we demonstr
 ate that glycyl tRNA synthetase (GARS1) mRNA is abundant in neurites and u
 ndergoes local translation\, producing GARS1 protein. Localized GARS1 prot
 ein is in close proximity to tRNAGly\, and disrupting this interaction imp
 airs local protein synthesis in neurites. Notably\, in a neuropathy-causin
 g mutant variant of GARS1\, we observed enhanced proximity to tRNAGly\, in
 dicating that altered GARS1– tRNAGly interactions may contribute to dise
 ase pathogenesis. These findings establish the functional importance of GA
 RS1 and tRNAGly in neuritic translation and suggest a mechanism for periph
 eral neuropathies due to mutations in GARS1. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM:  - https://technion.zoom
 .us/j/4885283424

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