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UID:1311@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250916T133000

DTEND;TZID=Asia/Jerusalem:20250916T140000

DTSTAMP:20250914T110634Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-valeri
 a-tsvichenko/

SUMMARY:MSc Graduate Seminar-  Valeria Tsvichenko [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/95522568296    Valeria Tsvichenko\n Affiliation: \n Host:P
 rof. Debbie Lindell \n Phage Resistance in Synechococcus sp. WH8109 \n\n&
 nbsp\;\n\nPhage resistance plays a central role in shaping cyanobacterial 
 population dynamics and their interactions with viruses in the ocean. The 
 coexistence of resistant and susceptible cells is likely one of the proces
 ses enabling hosts and phages to persist together. Yet the patterns and ge
 netic basis of resistance are only partially resolved. Here\, I examined g
 enetically distinct populations of Synechococcus sp. WH8109 and found that
  resistance to the cyanophages Syn9 and S-TIP37 was consistently density-d
 ependent across host populations. Whole genome sequencing of Syn9-resistan
 t cyanobacteria revealed mutations in nine genes in the resistant strains.
  In a complementary approach\, I investigated two porin-like genes previou
 sly implicated in resistance to phages S-TIP37 and Syn5. However\, heterol
 ogous binding assays in E. coli did not conclusively establish their role 
 in phage resistance. Together\, these studies integrate ecological and gen
 etic perspectives to advance understanding of the processes that govern ho
 st–phage coexistence in marine systems. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/95522568296

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