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UID:1351@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20260218T130000

DTEND;TZID=Asia/Jerusalem:20260218T133000

DTSTAMP:20260212T123953Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-yuanpu
 -sun/

SUMMARY:MSc Graduate Seminar-Yuanpu Sun [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/99663315043  Yuanpu Sun\n Affiliation: \n Host:Prof. Yael 
 Mandel-Gutfreund \n RBM25 Acts as a dual chromatin- and RNA-binding regula
 tor in Human Embryonic Stem Cells1\n\n \n\n&nbsp\;\n\nRNA-binding protein
 s are increasingly recognized to have chromatin-associated functions beyon
 d their canonical post-transcriptional roles. Here\, we show that RBM25 ex
 hibits dual RNA- and DNA-binding functions in human Embryonic Stem Cells. 
 At the RNA level\, RBM25 acts as a splicing factor\, while\, at the DNA le
 vel\, it is required for the binding of the Transcription regulator CEBPZ 
 to promoters of cell cycle–related genes. In contrast\, RBM25 and CEBPZ 
 bind to introns of silenced neuronal genes independently. Together\, these
  findings identify a functional RBM25–CEBPZ interaction that supports st
 em cell identity and prevents premature neuronal differentiation. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/99663315043

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