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UID:1122@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220913T133000

DTEND;TZID=Asia/Jerusalem:20220913T140000

DTSTAMP:20220906T065847Z

URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar/

SUMMARY:MSc Graduate Seminar [No Categories]
DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM  \n Affiliatio
 n: \n Host:\n What mechanism protects the heart from fasting-induced atrop
 hy?\n\nSkeletal muscles atrophy upon systemic fasting\, when blood glucose
  and insulin levels are low. However\, the heart is relatively protected\,
  and atrophy to a much lesser extent than skeletal muscles. We demonstrate
  that despite the low levels of circulating insulin\, insulin-PI3K-AKT sig
 naling is enhanced in the heart and promotes basal rates of protein synthe
 sis. The activation of this pathway reduces degradation of myofibrillar an
 d soluble proteins\, enabling preservation of cardiac muscle mass. Consist
 ently\, chemical labeling of cellular proteins followed by mass spectromet
 ry analysis indicated that proteasome and ribosome subunits are reduced in
  amounts. Maintenance of insulin-PI3K-AKT activity is critical for protect
 ing the heart from atrophy\, and the underlying mechanisms appear independ
 ent from the ligand insulin.\n\nZOOM Link: https://technion.zoom.us/j/947
 09397738 
LOCATION:hybrid- in the Faculty Auditorium/ZOOM

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DTSTART:20220325T030000

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