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UID:1125@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20221024T130000

DTEND;TZID=Asia/Jerusalem:20221024T130000

DTSTAMP:20221011T072435Z

URL:https://biology.technion.ac.il/en/seminars/ori-avinoam/

SUMMARY:Ori Avinoam - Department of Biomolecular Sciences\, Weizmann Instit
 ute of Science [No Categories]
DESCRIPTION:Location: Faculty of Biology Auditorium  Ori Avinoam\n Affiliat
 ion: Department of Biomolecular Sciences\, Weizmann Institute of Science\n
  Host:Sagi Levy and Benjamin Podbilewicz  \n Exocytosis by membrane crumpl
 ing maintains homeostasis during exocrine secretion\n\nDynamic membrane re
 modeling is essential for life. Cells\, organelles\, and vesicles must con
 stantly acquire\, maintain and modify their shape and composition to fulfi
 ll a plethora of important physiological functions ranging from neuronal t
 ransmission to fertilization and muscle contraction. My lab focuses on elu
 cidating the membrane remodeling pathways that mediate the trafficking of 
 material and information in and between cells. These include endocytosis\,
  exocytosis\, extracellular-vesicles\, and cell-to-cell fusion. We are com
 mitted to gaining previously inaccessible insights into the molecular mech
 anisms and physiological functions of membrane remodeling in the context o
 f tissue morphogenesis and homeostasis. To this end\, we take an interdisc
 iplinary approach combining the strengths of biochemistry\, genetics\, and
  multimodal imaging\, including the development of three-dimensional corre
 lative light and electron microscopy (CLEM) approaches. We apply these sta
 te-of-the-art techniques to a variety of cell culture and in vivo models\,
  including flies and mice\, to pursue several major research directions\, 
 which include membrane remodeling during exocytosis of large secretory ves
 icles and differentiation and fusion of vertebrate skeletal muscles. These
  systems offer the unique opportunity to understand how membrane remodelin
 g processes adapt to the changing demands of cellular life and the life of
  the organism. 
LOCATION:Faculty of Biology Auditorium

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