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UID:933@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20201216T130000

DTEND;TZID=Asia/Jerusalem:20201216T140000

DTSTAMP:20210802T125903Z

URL:https://biology.technion.ac.il/en/seminars/ph-d-graduate-seminar-vered
 -cohen-from-the-lab-of-doctor-meiri-david-2/

SUMMARY:Ph.D. Graduate Seminar-Vered Cohen  From the Lab of Doctor Meiri D
 avid [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Breastcanceris not a sin
 gle disease\, it is comprised of many biologically differentfeatures with 
 distinct pathological and clinicalimplications. Accumulating evidence sugg
 est breast cancers with different histopathological andbiological features
  exhibit different behaviors that lead to differenttreatment responses\, a
 nd should be handled by different therapeutic strategies.In ERa-positivetu
 mors\, adjustive endocrine therapy\, such as tamoxifen (TAM)\, is the stan
 dardfor a 5 years course.  However\, almosthalf of the patients that star
 t tamoxifen therapy do not complete the wholecourse. Poor adherence to tam
 oxifen has been associated with many reasonsincluding severe side effects 
 such as hot flashes\, pain and bleeding. In cancertreatment\, Cannabisis b
 eing primarily used as palliative care to alleviate pain\, relieve nauseaa
 nd stimulate appetite. However\, asidefrom these palliative actions\, exte
 nsive preclinical research demonstratedthat phytocannabinoids\, theunique 
 active components of the Cannabisplant\, can trigger an antitumor response
  in different cancer models. Inthis study\, we found a unique Cannabisstra
 in (CANN14) that has a synergistic effect with TAM on ERa-positivebreast c
 ancer cells. CANN14 sensitizes the cells to TAM’s effect\, allowing fora
  lower TAM concentration. Moreover\, we isolated the phytocannabinoidsresp
 onsible for the effect: THC\, CBN and the novel phytocannabinoid331-18b. I
 n a xenograft model\, tumor growth was suppressed significantly withthe co
 mbined synergistic effect of TAM and CANN14. A combination of THC\, CBNand
  331-18b  in the same concentrationsas in CANN14 had a similar effect to 
 the whole CANN14 on breast cancer cells.Furthermore\, a higher concentrati
 on of 331-18b significantly sensitized thecells to lower TAM concentration
  by itself. The mechanism of breast cancer celldeath following exposure to
  CANN14 or the three pure cannabinoids involves areduction in ERaexpressio
 n and translation\, as well as in its activity as a transcriptionfactor. T
 hese findings will allow\, in thefuture\, to make a compatible match betwe
 en the Cannabisstrain and specific breast cancer tumor features. As a resu
 lt\, treatment dosagewill decrease and the patients’ quality of life wil
 l improve.       

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DTSTART:20201025T010000

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