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UID:1358@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20260323T130000

DTEND;TZID=Asia/Jerusalem:20260323T140000

DTSTAMP:20260311T090844Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-3/

SUMMARY:PhD Graduate Seminar- Ofir Levin-Piaeda [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/5447024192        Ofir Levin-Piaeda \n Affiliation: \n Hos
 t:Prof. Reiter Yoram\n &nbsp\;\n\nBeyond Signal Strength: Combining biophy
 sical properties with co-stimulatory signals to design optimal TCRL-based 
 CAR-T cells\n\n&nbsp\;\n\nTo address the limited efficacy of CAR T-cell th
 erapy in solid tumors\, we systematically optimized the intracellular sign
 aling domains of TCR-Like (TCRL) CARs targeting melanoma. Our research ide
 ntifies the advanced 3rd-generation CAR and the dual-signal novel hybrid c
 onstructs as lead candidates\, demonstrating superior targeted cytotoxicit
 y across varying antigen densities without triggering immediate inhibitory
  overload. Crucially\, transcriptomic analysis reveals these engineered T-
 cells succeed by reprogramming their genetic profile toward "metabolic int
 elligence"—prioritizing long-term metabolic fitness over mere signal amp
 lification to prevent exhaustion and sustain anti-tumor activity. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/5447024192

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