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UID:1170@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230503T130000

DTEND;TZID=Asia/Jerusalem:20230503T140000

DTSTAMP:20230419T094311Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-amir-a
 rgoetti/

SUMMARY:PhD Graduate Seminar- Amir Argoetti [No Categories]
DESCRIPTION:Location: Faculty Of Biology Auditorium: https:https://technion
 .zoom.us/j/91517111637  Amir Argoetti\n Affiliation: \n Host:Prof. Mandel-
 Gutfreund Yael\n Transcription Factors-RNA interaction: a new layer of cel
 lular regulation\n\nGene expression is a complex process tightly regulated
  by various proteins\, including DNA-binding proteins (DBPs) and RNA-bindi
 ng proteins (RBPs). However\, little is known about proteins that can bind
  both DNA and RNA\, referred to as DNA-RNA binding proteins (DRBPs). In th
 is study\, we identified over 40 transcription factors (TFs) including the
  pluripotent factors OCT4 and STAT3\, the latter known also for it’s rol
 es in immune system and cancer progression. Using enhanced-CLIP we found t
 hat STAT3 directly interacts the long non-coding RNA involved in DNA stabi
 lity\, NORAD. Further\, by conducting extensive functional analyses we sho
 w that the binding of NORAD to STAT3 has a key role in anti-viral response
  both in pluripotent and fully differentiated cells. In healthy cells\, it
  effectively silences the antiviral pathway\, while upon infection it allo
 ws a rapid shift towards activation of\, viral defense genes. Intriguingly
 \, we found that the function of NORAD is unique to humans and not observe
 d in mice\, despite the conservation of other functions across mammalian e
 volution.\n\nThe identification of a direct interaction between STAT3 and 
 NORAD\, its mechanism and its function\, adds a new dimension of knowledge
  regarding DRBPs' roles in rapid cellular response to the environment. Add
 itionally\, this human-specific function of NORAD underscores the contribu
 tion of this study to understanding species-specific gene regulation.\n\n&
 nbsp\; 
LOCATION:Faculty Of Biology Auditorium: https:https://technion.zoom.us/j/91
 517111637

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