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UID:1189@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230808T130000

DTEND;TZID=Asia/Jerusalem:20230808T140000

DTSTAMP:20230717T091311Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-bar-co
 hen/

SUMMARY:PhD Graduate Seminar- Bar Cohen [No Categories]
DESCRIPTION:Location: hybrid- in the Faculty Auditorium /ZOOM:https://techn
 ion.zoom.us/j/92052655538  \n Affiliation: \n Host:Prof. Arava Yoav\n mRNA
 s Co-transport with Mitochondria in Neuronal Cells: Sequence Elements and 
 Protein Factors\nNeurons are polarized cells with high energetic demands\,
  which are highly dependent on localized translation of nuclear-encoded mR
 NAs. Yet\, the transport mechanisms of the translation machinery component
 s\, namely the mRNA\, are largely unknown. We showed that mRNAs of nuclear
 -encoded mitochondrial genes are associated with mitochondria\, in both mo
 use neural-like cell lines and primary neurons. Furthermore\, live-imaging
  of mRNAs\, revealed that one of these mRNAs\, Cox7c\, is not only associa
 ted but also co-transported with moving mitochondria along neurites. Inter
 estingly\, the Cox7c mRNA coding sequence\, and specifically the predicted
  mitochondrial targeting sequence (MTS)\, rather than its 3’untranslated
  region\, was the significant domain for the mechanism. Our results sugges
 t that mRNAs encoding mitochondrial proteins are associated and transporte
 d with mitochondria in a manner that might involve translation. Genome-wid
 e analysis of mitochondria-associated mRNAs revealed diverse groups of mRN
 As\, implying a broad phenomenon. To identify the mediators of this associ
 ation we performed a proteomic identification of mRNA-associated proteins 
 and investigated key candidate’s role in the co-transport. Together\, th
 e results support the idea that mitochondria can serve as mRNA shuttles an
 d help regulate the distribution of mRNAs in specific locations within neu
 rons. 
LOCATION:hybrid- in the Faculty Auditorium /ZOOM:https://technion.zoom.us/j
 /92052655538

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