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UID:1167@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230404T130000

DTEND;TZID=Asia/Jerusalem:20230404T140000

DTSTAMP:20230316T121733Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-bella-
 ben-oz/

SUMMARY:PhD Graduate Seminar- Bella Ben-Oz [No Categories]
DESCRIPTION:Location: Faculty Of Biology Auditorium:https://technion.zoom.u
 s/j/94957315009   Bella Ben-Oz\n Affiliation: \n Host:Associate Prof. Nabi
 eh Ayoub\n A dual role of RBM42 in modulating splicing and translation dur
 ing DNA damage response: A spotlight on CDKN1A/p21 gene\n\n&nbsp\;\n\nAbst
 ract\n\np53-mediated cell cycle arrest during DNA damage is dependent on t
 he induction of p21 protein\, encoded by the CDKN1A gene. p21 inhibits cyc
 lin-dependent kinases required for cell cycle progression to guarantee acc
 urate repair of DNA lesions. Hence\, fine-tuning of p21 levels is crucial 
 for maintaining genomic stability. Currently\, the multilayered regulation
  of p21 levels during DNA damage is not fully understood. Herein\, we ide
 ntified the human RNA binding motif protein 42 (RBM42) as a novel regulato
 r of p21 levels during DNA damage. Genome-wide transcriptome and interacto
 me analysis revealed that RBM42 alters the expression of p53-regulated gen
 es during DNA damage. Specifically\, we demonstrated that RBM42 facilitate
 s CDKN1A splicing during DNA damage by counteracting the splicing inhibito
 ry activity of RBM4 protein. Unexpectedly\, we also showed that RBM42 toge
 ther with its proximity translation factor\, CUGBP1\, underpins translatio
 n of various splicing targets\, including CDKN1A\, following DNA damage. C
 oncordantly\, transcriptome-wide mapping of RBM42-RNA interactions using e
 CLIP revealed that following DNA damage\, RBM42 binds the 5’UTR of hundr
 eds of genes. These findings suggest that RBM42 is primarily involved in m
 odulating DNA damage-induced translation. Collectively\, our data show tha
 t RBM42 couples splicing and translation machineries to fine-tune gene exp
 ression during DNA damage response.\n\n&nbsp\; 
LOCATION:Faculty Of Biology Auditorium:https://technion.zoom.us/j/949573150
 09

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