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UID:961@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20210615T130000

DTEND;TZID=Asia/Jerusalem:20210615T140000

DTSTAMP:20210802T125905Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-cfir-d
 avid-2/

SUMMARY:PhD Graduate Seminar-Cfir David [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n The regulation of Tet1 b
 y steroidhormones in proliferating gonadotrope precursor cellsThe hydroxym
 ethylase\, Tet1\, plays amajor role in regulating gene expression\, and it
 s knockdown specificallyaffects fertility. Reproductive function is activa
 ted by hormones produced ingonadotrope cells of the pituitary gland\, whic
 h are tightly controlled by thegonadal steroids. We found that Tet1 is exp
 ressed in proliferatinggonadotrope precursor cells\, but is down-regulated
  to allow their maturation\,and hypothesized that gonadal steroids might b
 e responsible for thisrepression. Exposure to androgens or estrogens inhib
 ited Tet1 expressionand we have demonstrated two distinct mechanisms. Firs
 t\, the steroid receptorsbind several regulatory regions upstream of Tet1 
 and induce changes tothe chromatin structure and histone modifications to 
 hinder Tet1transcription initiation. In addition\, estradiol lowers Tet1 m
 RNAstability by decreasing the m6A methylation. Asides from playing a cruc
 ial rolein the central control of reproduction\, the regulationof Tet1 exp
 ression by gonadal steroid hormones has implications in the context of cel
 l proliferationand differentiation in other steroid-responsive tissues\, i
 ncludingsteroid-dependent cancers. 

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