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UID:1267@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250212T130000

DTEND;TZID=Asia/Jerusalem:20250212T140000

DTSTAMP:20250203T110712Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-david-
 ezuz/

SUMMARY:PhD Graduate Seminar- David Ezuz [No Categories]
DESCRIPTION:Location: Biology auditorium and by ZOOM:https:https://technion
 .zoom.us/j/8372688367   David Ezuz\n Affiliation: \n Host:dr. Noga Ron-Har
 el\n Heme toxicity in the aged spleen impairs T-cell immunity through iron
  deprivation\n\n&nbsp\;\n\nMechanisms of T cell aging involve cell-intrins
 ic alterations and interactions with other immune and stromal cells. Here\
 , we investigated how the tissue microenvironment influences T-cell aging 
 trajectories. Spleen-derived lymphocytes exhibited greater functional decl
 ine compared to those from lymph nodes\, with proteomic analysis revealing
  increased expression of heme detoxification and iron storage proteins in 
 aged spleen-derived lymphocytes. Exposure to the aged spleen microenvironm
 ent or to heme induced multiple aging phenotypes in young lymphocytes\, in
 cluding reduced proliferation and upregulation of CD39. T cells survived t
 he hostile microenvironment of the aged spleen by restricting iron uptake 
 and maintaining low labile iron pools. Nevertheless\, vaccination response
 s in aged mice were enhanced by timed iron infusions. Our findings undersc
 ore a trade-off between T cell survival and function in the aged host\, an
 d highlight the bidirectional relationship between T cells and their micro
 environment. Understanding these mechanisms will inform strategies to enha
 nce immune responses in the elderly. 
LOCATION:Biology auditorium and by ZOOM:https:https://technion.zoom.us/j/83
 72688367 

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