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UID:1329@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20251112T130000

DTEND;TZID=Asia/Jerusalem:20251112T140000

DTSTAMP:20251105T082510Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-dharan
 ibalan-kasiviswanathan/

SUMMARY:PhD Graduate Seminar-Dharanibalan Kasiviswanathan [No Categories]
DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOMhttps://technion.zo
 om.us/j/99692061614  Dharanibalan Kasiviswanathan\n Affiliation:  \n Host:
  Associate Prof. Shenhav Shemer\n &nbsp\;\n\nA controlled in vitro model o
 f disuse atrophy reveals that skeletal muscle drives its own wasting via e
 xtracellular vesicles \n\nWe established a controlled in vitro model of m
 uscle disuse using simulated microgravity\, eliminating systemic influence
 s. This model accurately recapitulates transcriptional and proteomic signa
 tures of inactive muscles in vivo. We discovered that extracellular vesicl
 es (EVs) secreted by unloaded myotubes induce catabolic signaling in recip
 ient muscle cells. Our findings reveal that skeletal muscle can drive its 
 own disuse atrophy through EV-mediated communication. 
LOCATION:Faculty Of Biology Auditorium/ZOOMhttps://technion.zoom.us/j/99692
 061614

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