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UID:967@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20210714T130000

DTEND;TZID=Asia/Jerusalem:20210714T140000

DTSTAMP:20210802T125905Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-egor-s
 edov-2/

SUMMARY:PhD Graduate Seminar-Egor Sedov [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Anchoredcells of the bas
 al epidermis constantly undergo proliferation in an overcrowdedenvironment
 . One important regulator of epidermal proliferation is YAP\, whichcan be 
 controlled by both cell-matrix and cell-cell interactions. During myPh.D.\
 , I discovered that Thy1\, a GPI anchored protein\, inhibits epidermal YAP
 activity through converging molecular mechanisms. We found that Thy1 defic
 iencyleads to increased adhesion by activating the Integrin-β1/Srcmodule.
  Notably\, regardless of high cellular densities\, the absence of Thy1lead
 s to the dissociation of an adherensjunction complex that enables the rele
 ase and translocation of YAP. Due toincreased YAP-dependent proliferation\
 , Thy1-/-micedisplay enhanced wound repair and YAP-dependent hair follicle
  regeneration.Taken together\, our work reveals Thy1 as a critical regulat
 or of cell-matrixand cell-cell interactions that controls YAP activity in 
 skin homeostasis\,regeneration and tumorigenesis. 

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DTSTART:20210326T030000

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