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UID:932@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20201209T130000

DTEND;TZID=Asia/Jerusalem:20201209T140000

DTSTAMP:20210802T125903Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-einas-
 abu-zhayia-2/

SUMMARY:PhD. Graduate Seminar-  Einas Abu Zhayia [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Identification of a nove
 l pathway to ensure double strand break-inducedtranscriptional silencing a
 nd repairDouble-strand break (DSB) are the most cytotoxic form DNA damagea
 nd defective DSB repair leads to genomic instabilities that may augment ca
 rcinogenesis.DSBs trigger local transcriptional silencing in an ATM\, DNA-
 PK\, and PARP1-dependentmanner. During my PhD\, I identified a previously 
 unrecognized dual role ofchromodomain Y-like (CDYL1) protein in fortifying
  double-strand break (DSB)-inducedtranscriptional silencing and homology-d
 irected repair. Mechanistically\, CDYL1ensures DSB-induced transcriptional
  silencing by local stimulation of therepressive methyl mark H3K27me3 and 
 down regulation of histone lysinecrotonylation. Unexpectedly\, while inhib
 iting the reduction in lysinecrotonylation at DSB sites alleviates transcr
 iptional silencing\, the integrityof HDR of DSBs remains intact. Our resul
 ts uncoupled therefore the repair andthe silencing activity of CDYL1 at DS
 Bs. In a broader context\, our dataaddressed a long-standing question in t
 he field concerning the functionalrelationship between HDR and DSB-induced
  transcriptional silencing and suggestthat they may occur independently.  

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