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UID:1271@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250319T130000

DTEND;TZID=Asia/Jerusalem:20250319T140000

DTSTAMP:20250306T092540Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-haya-d
 ahamshy/

SUMMARY:PhD Graduate Seminar- Haya Dahamshy [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni
 on.zoom.us/j/93244858609  Haya Dahamshy\n Affiliation: \n Host:Dr.  Asaf B
 ester\n "Identification and characterization of DNA damage response lncRNA
  by spatial-temporal analysis”\nLong non-coding RNAs (lncRNAs) are emerg
 ing as key regulators of cellular function\, with their spatial and tempor
 al expression playing a crucial role in maintaining homeostasis. Among the
 m\, LINC00944 stands out for its dynamic response to DNA damage\, showing 
 a striking increase in nuclear expression following the DNA damage respons
 e (DDR). This lncRNA actively shapes cellular fate by regulating the cell 
 cycle through p21 and driving apoptosis via BCL2 and γ-H2AX. Beyond its r
 ole in DDR\, our findings reveal an unexpected and significant influence o
 f LINC00944 on inflammation and immune response pathways. This dual functi
 onality suggests that LINC00944 is not just a participant in DNA repair bu
 t also a key player in broader stress response networks. Unraveling its me
 chanisms could open new avenues for understanding how cells balance surviv
 al\, repair\, and immune activation in response to damage 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/
 93244858609

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DTSTART:20241027T010000

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