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UID:1205@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240313T130000

DTEND;TZID=Asia/Jerusalem:20240313T140000

DTSTAMP:20240130T094318Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-hodaya
 -baruchi-farber/

SUMMARY:PhD Graduate Seminar- Hodaya Baruchi Farber [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/7465533221   Hodaya Baruchi Farber\n Affiliation: \n Host:Pr
 of. Shlomi Tomer\n Identifying metabolic alterations and vulnerabilities i
 n therapy-induced senescent cancer cells\n\nCellular senescence\, cell cyc
 le arrest due to stress conditions\, is a defense mechanism against accumu
 lation of mutations and tumorigenesis. Therapy-induced senescence (TIS) is
  caused by treating cancer cells with sub-cytotoxic doses of chemotherapy.
  Senescence was thought of as irreversible\, hence\, serving as a valid en
 d-point for cancer therapy\, inhibiting cancer progression. New evidence r
 eveals ways for escaping senescence\, resulting in senescent cancer cells 
 which are resistant to classical chemotherapy\, which can in time lead to 
 cancer relapse. Moreover\, the senescence process is accompanied by senesc
 ence-associated secretory phenotype (SASP)\, involving the secretion of in
 flammatory cytokines that enhances inflammation in the tumor microenvironm
 ent and cancer progression. Our research aims to identify cellular metabol
 ic alterations and vulnerabilities associated with TIS. To address this ch
 allenge\, we used LC-MS based metabolomics and isotope tracing to characte
 rize metabolic alterations in cancer cell lines treated with the chemother
 apeutic drug doxorubicin to induce TIS. Isotope tracing experiments with 1
 3C glucose and glutamine revealed decreased pyruvate dehydrogenase (PDH) a
 ctivity in senescent cells (versus non-proliferating quiescent cells) and 
 an overall decrease in mitochondrial respiration. We further observe an in
 crease in the relative contribution of glucose versus glutamine-derived TC
 A cycle anaplerosis via pyruvate carboxylase in TIS. Additionally\, our li
 pidomics results show major changes in the intracellular concentration of 
 lipids synthesized from recycled FAs. Our results call for further researc
 h on characterizing metabolic alterations associated with TIS and finding 
 of induced essentiality of metabolic enzymes that could be targeted for th
 erapeutic purposes. 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /7465533221

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DTSTART:20231029T010000

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