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UID:1148@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230111T130000

DTEND;TZID=Asia/Jerusalem:20230111T140000

DTSTAMP:20221229T073424Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-ilana-
 alona-goor/

SUMMARY:PhD Graduate Seminar-Ilana (Alona) Goor [No Categories]
DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/99170022526  Ilana (Alona) Goor\n Affiliation: \n Host:Prof.
  Yoram Reiter\n Study of Antigen Presentation and Antigen-Specific Immunom
 odulation in Multiple Sclerosis by T cell Receptor-mimic Antibodies\nDurin
 g autoimmune diseases\, like Multiple Sclerosis (MS)\, the immune system i
 s downregulated in a non-specific manner in order to reduce inflammation. 
 Consequently\, targeting and specifically inhibiting autoreactive T cells 
 is highly desirable as a treatment for autoimmune disease. We hypothesize 
 that during the inflammatory process in MS\, APCs can present several myel
 in derived epitopes simultaneously and consequently activate a variety of 
 autoreactive T cells. Accordingly\, targeting one of these epitopes with T
  cell receptor- mimic (TCRm) antibody (Ab) could result in the elimination
  of specific APCs\, thus prevent epitope spreading\, decrease myelin-speci
 fic T cells` activation\, affect differentiated T cell p\nopulations and m
 ost importantly decrease disease exacerbation. To this end\, we have isola
 ted and characterized two TCRm Abs directed against MOG 35-55/ HLA-DR2 epi
 topes. These TCRm Abs can obtain their function via two mechanisms of acti
 on: (i) block peptide-MHC interactions between pathogenic T cells and APCs
 \, and (ii) specifically eliminate APCs presenting MS-associated autoantig
 ens by ADCC or CDC. The TCRm Abs exhibit specific inhibition of T cell pro
 liferation in vitro and ex vivo. Moreover\, the TCRm Abs were able to medi
 ate specific killing of MOG- presenting APCs. According to these data\, an
 tigen-specific TCRm Abs are valuable molecules that may facilitate importa
 nt studies related to antigen presentation in autoimmunity and contribute 
 to the development of innovative therapeutic and diagnostic agents for tre
 ating autoimmune disorders such as MS. 
LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /99170022526

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