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UID:1098@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220411T143000

DTEND;TZID=Asia/Jerusalem:20220411T153000

DTSTAMP:20220713T072649Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-inbar-
 magid-gold/

SUMMARY:PhD Graduate Seminar-Inbar Magid Gold [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title: The regulatory ro
 le of free ISG15Interferons(IFNs) are a group of cytokinesinduced by viral
  infection. IFN production leads to a series of protein conformationalrear
 rangements and interactions as well as production of specific proteins. In
 terferonStimulated Gene 15 (ISG15) is one protein which is highly induced 
 in responseto IFN production. ISG15 is an abundant ubiquitin-like post-tra
 nslationmodification that\, similar to Ubiquitin (Ub)\, marks hundreds of 
 cellularproteins following viral or bacterial infections. ISG15’s target
 s include bothviral proteins and cellular proteins spanning an array of ce
 llular compartmentsand metabolic pathways. As opposed to Ub\, that is cons
 umed almost completelyand is hardly present in its free form\, ISG15 can b
 e found in the cell in twoforms: free ISG15 and as a part of a chain. It i
 s known that free ISG15 can besecreted and act as a cytokine like protein\
 , inducing the IFN pathway of theneighboring cells. In our research\, we f
 ound a different regulatory role of thefree ISG15. By investigating its bi
 nding partners\, we found that ISG15 can bindthe transcription factor that
  enables its production in the first place\, thusacting as autoregulator o
 f its own level and effect the innate immune responseof the cell.   

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