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UID:1157@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230201T130000

DTEND;TZID=Asia/Jerusalem:20230201T140000

DTSTAMP:20230115T131149Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-iris-w
 yrobnik/

SUMMARY:PhD Graduate Seminar- Iris Wyrobnik [No Categories]
DESCRIPTION:Location:  hybrid- in the Faculty Auditorium/ZOOM:   https://te
 chnion.zoom.us/j/94968602637  \n Affiliation:  Iris Wyrobnik\n Host:Associ
 ate Prof. David Meiri Lab\n &nbsp\;\n\nDecreased melanoma CSF-1 secretion 
 by Cannabigerol treatment reprograms regulatory myeloid cells and reduces 
 tumor progression\n\n&nbsp\;\n\nDuring solid tumor progression\, the tumor
  microenvironment (TME) evolves into a highly immunosuppressive milieu. Ke
 y players in the immunosuppressive environment are regulatory myeloid cell
 s\, including Myeloid-derived suppressor cells (MDSCs) and tumor-associate
 d macrophages (TAMs)\, which are recruited and activated via tumor-secrete
 d cytokines such as colony-stimulating factor 1 (CSF-1). Therefore\, the d
 epletion of tumor-secreted cytokines is a leading anticancer strategy. Her
 e\, we found that CSF-1 secretion by melanoma cells is decreased following
  treatment with Cannabis extracts. Cannabigerol (CBG) was identified as th
 e bioactive cannabinoid responsible for the effects. Conditioned media fro
 m cells treated with pure CBG or the high-CBG extract reduced the expansio
 n and macrophage transition of the monocytic-MDSC subpopulation. Treated M
 O-MDSCs also expressed lower levels of iNOS\, leading to restored CD8+ T-c
 ell activation. Tumor-bearing mice treated with CBG presented reduced tumo
 r progression\, lower TAM frequencies and reduced TAM/M1 ratio. A combinat
 ion of CBG and αPD-L1 was more effective in reducing tumor progression an
 d increasing the infiltration of activated cytotoxic T-cells than each tre
 atment separately. We show a novel mechanism for CBG in modulating the TME
  and enhancing immune checkpoint blockade therapy\, underlining its promis
 ing therapeutic potential for the treatment of a variety of tumors with el
 evated CSF-1 expression. 
LOCATION: hybrid- in the Faculty Auditorium/ZOOM:   https://technion.zoom.u
 s/j/94968602637

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DTSTART:20221030T010000

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