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UID:1339@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20251231T130000

DTEND;TZID=Asia/Jerusalem:20251231T140000

DTSTAMP:20251204T100841Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-johann
 es-venezian/

SUMMARY:PhD Graduate Seminar-Johannes Venezian [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni
 on.zoom.us/j/99903047740  Johannes Venezian\n Affiliation: \n Host:Dr. Aya
 la Shiber \n Evolution of Protein Folding and Assembly Pathways: Decipheri
 ng the Characteristics of Divergent Co-translational Assembly Pathways\n\n
 Protein-protein interactions are at the heart of all cellular processes\, 
 with the ribosome emerging as a platform that orchestrates nascent-chain i
 nterplay dynamics. In this seminar\, I will present a multidisciplinary st
 udy combining in vivo and in silico approaches to capture snapshots of t
 he translation process through various methods\, such as selective ribosom
 e profiling\, all-atom molecular dynamics simulations\, and AlphaFold-base
 d predictions. These approaches elucidate the interplay of ribosome-associ
 ated factors that guide the folding and assembly pathways of emerging poly
 peptide chains. Focusing on the divergent folding and assembly pathways of
  the N-terminal acetyltransferase complex family to gain mechanistic insig
 ht—and expanding the analysis to the proteome scale—we discovered that
  assembly is driven by high-energy interface 'hotspots' that anchor mutual
 ly stabilizing subunits. We further demonstrate that these structural sign
 atures can accurately predict co-translational assembly across species and
  that disrupting these hotspots is linked to aggregation and neurodegenera
 tive disease. 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/
 99903047740

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