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UID:1357@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20260316T130000

DTEND;TZID=Asia/Jerusalem:20260316T140000

DTSTAMP:20260311T081001Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jonath
 an-greenbaum-2/

SUMMARY:PhD Graduate Seminar-Jonathan Greenbaum [No Categories]
DESCRIPTION:Location:  Hybrid - in the Faculty Auditorium /ZOOM: https://te
 chnion.zoom.us/j/94149580805  Jonathan Greenbaum\n Affiliation: \n Host:Pr
 of. Debbie Lindell \n “Host availability effects on evolution of general
 ist and specialist cyanophages”\n\nObligate parasites such as bacterioph
 ages are dependent on the availability of a sensitive host to persist. Nat
 ural environments pose challenges for survival\, with periods of unavailab
 ility of such a host and gradual loss of infectivity of phages. Despite th
 e importance of host availability to bacteriophages in natural environment
 s\, knowledge regarding evolution of ecologically prevalent bacteriophages
  is lacking. Here\, we characterized the evolution of cyanobacteria-infect
 ing bacteriophages (cyanophages) when propagating in the presence of a sen
 sitive host. In addition\, we characterized cyanophage evolution in the pr
 esence of increasing amounts of distinct resistant strains to which they c
 an attach\, while reducing the amount of sensitive host availability. Most
  cyanophage populations adapted to better infect the sensitive host. No ev
 idence for changes in host range was observed. Whole-genome sequencing rev
 ealed patterns of convergent evolution\, host availability-specific mutati
 ons\, and genes associated with adaptation. Specifically\, we found a puta
 tive holin\, a common phage protein not previously characterized in marine
  cyanophages\, that affects the lengtah of the infection cycle. In additio
 n\, we found a decrease in attachment to both \n\n&nbsp\;\n\nsensitive and
  resistant strains\, suggesting a balance between infection characteristic
 s beneficial in some host availabilities\, and detrimental in others. In a
 ddition\, we found that cyanophage evolution can have an unexpected effect
  on the growth of cyanobacteria not involved in the process of evolution. 
 Together\, these findings shed light on the complexity of cyanophage-cyano
 bacteria interactions in natural environments\, highlighting some unexpect
 ed outcomes of these interactions for cyanophage persistence strategies an
 d evolution of infection characteristics.\n\n&nbsp\; 
LOCATION: Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.u
 s/j/94149580805

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