BEGIN:VCALENDAR

VERSION:2.0

PRODID:-//wp-events-plugin.com//7.2.2.1//EN

TZID:Asia/Jerusalem

X-WR-TIMEZONE:Asia/Jerusalem
BEGIN:VEVENT

UID:1356@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20260330T130000

DTEND;TZID=Asia/Jerusalem:20260330T140000

DTSTAMP:20260323T123518Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jonath
 an-greenbaum/

SUMMARY:PhD Graduate Seminar-Jonathan Greenbaum [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/94149580805  Jonathan Greenbaum\n Affiliation: \n Host:Pro
 f. Debbie Lindell \n Host availability effects on evolution of generalist 
 and specialist cyanophages\n\nObligate parasites such as bacteriophages ar
 e dependent on the availability of a sensitive host to persist. Natural en
 vironments pose challenges for survival\, with periods of unavailability o
 f such a host and gradual loss of infectivity of phages. Despite the impor
 tance of host availability to bacteriophages in natural environments\, kno
 wledge regarding evolution of ecologically prevalent bacteriophages is lac
 king. Here\, we characterized the evolution of cyanobacteria-infecting bac
 teriophages (cyanophages) when propagating in the presence of a sensitive 
 host. In addition\, we characterized cyanophage evolution in the presence 
 of increasing amounts of distinct resistant strains to which they can atta
 ch\, while reducing the amount of sensitive host availability. Most cyanop
 hage populations adapted to better infect the sensitive host. No evidence 
 for changes in host range was observed. Whole-genome sequencing revealed p
 atterns of convergent evolution\, host availability-specific mutations\, a
 nd genes associated with adaptation. Specifically\, we found a putative ho
 lin\, a common phage protein not previously characterized in marine cyanop
 hages\, that affects the length of the infection cycle. In addition\, we f
 ound a decrease in attachment to both sensitive and resistant strains\, su
 ggesting a balance between infection characteristics beneficial in some ho
 st availabilities\, and detrimental in others. In addition\, we found that
  cyanophage evolution can have an unexpected effect on the growth of cyano
 bacteria not involved in the process of evolution. Together\, these findin
 gs shed light on the complexity of cyanophage-cyanobacteria interactions i
 n natural environments\, highlighting some unexpected outcomes of these in
 teractions for cyanophage persistence strategies and evolution of infectio
 n characteristics. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/94149580805

END:VEVENT

BEGIN:VTIMEZONE

TZID:Asia/Jerusalem

X-LIC-LOCATION:Asia/Jerusalem

BEGIN:DAYLIGHT

DTSTART:20260327T030000

TZOFFSETFROM:+0200

TZOFFSETTO:+0300

TZNAME:IDT

END:DAYLIGHT

END:VTIMEZONE
END:VCALENDAR