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UID:1303@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250826T130000

DTEND;TZID=Asia/Jerusalem:20250826T140000

DTSTAMP:20250724T080246Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jonath
 an-ram/

SUMMARY:PhD Graduate Seminar-Jonathan Ram [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/93938772814  Jonathan Ram\n Affiliation: \n Host:Prof. Mic
 hael Glickman\n &nbsp\;\n\nNew players in mitochondrial protein import qua
 lity control13\n\nMitochondria import most of their proteins from the cyto
 sol via dedicated channels in the outer membrane. This process is complex\
 , and import can occasionally stall when proteins get stuck in transit. Wh
 ile the role of the ubiquitin–proteasome system (UPS) in this context is
  well established in yeast\, it remains poorly understood in mammalian cel
 ls. We performed a proximity-based screen to identify UPS components near 
 the mitochondrial import channel and uncovered novel interactors. Among th
 em\, we identified UBXD8 and investigated its role in the quality control 
 of mitochondrial protein import. These findings not only expand our unders
 tanding of mitochondrial proteostasis in mammals\, but also reveal UBXD8 a
 s a potential regulator of import channel homeostasis. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/93938772814

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