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UID:1299@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250722T130000

DTEND;TZID=Asia/Jerusalem:20250722T140000

DTSTAMP:20250702T150957Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-joshua
 -hazan/

SUMMARY:PhD Graduate Seminar-Joshua Hazan [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/94162344686  Joshua Hazan \n Affiliation: \n Host:Dr. Assa
 f Bester \n &nbsp\;\n\nA toolkit to decipher mechanistic insights of long 
 non-coding RNAs based on guided CRISPR screens\n\nLong non-coding RNAs (ln
 cRNAs) are a large and diverse group of non-protein-coding genes whose fun
 ctions span a wide range of cellular processes in healthy cells and in the
  progression of various diseases. Despite their potential roles in many ma
 jor cellular processes\, the molecular function of the majority of lncRNAs
  remains unknown. To improve the strategy for lncRNA identification\, we d
 eveloped two strategies to discover novel functional lncRNAs and character
 ize their molecular mechanisms of action. First\, we developed a machine l
 earning called INFLAMeR to predict functional lncRNAs in a cell type-speci
 fic manner. INFLAMeR showed high predictive accuracy\, and we saw that the
  lncRNA SNHG6 affected haematopoiesis in leukaemia cells.Second\, we desig
 ned a compact CRISPRi-based screening strategy called SPPARCL to identify 
 new lncRNAs that function in diverse cellular stresses. Through this\, we 
 saw that LINC00680 affects tRNA expression and ribosome assembly. Together
 \, these tools offer important new ways to identify lncRNAs that function 
 in health and disease. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/94162344686

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