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UID:1266@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250205T130000

DTEND;TZID=Asia/Jerusalem:20250205T140000

DTSTAMP:20250202T134644Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-junyi-
 he/

SUMMARY:PhD Graduate Seminar-Junyi He [No Categories]
DESCRIPTION:Location: Biology auditorium and by ZOOM:https://technion.zoom.
 us/j/9592170138?omn=99221930350   Junyi He\n Affiliation: \n Host:Dr. Ayal
 a Shiber  \n Identification and characterization of novel quality control 
 factors acting in a co-translational manner\n&nbsp\;\n\nAt the critical ju
 nction of translation and protein folding\, the ribosome serves as a centr
 al hub\, orchestrating the actions of various factors that facilitate the 
 maturation of emerging polypeptide-chains. However\, ribosome associated q
 uality control mechanisms\, safeguarding the cell from early misfolding\, 
 remain largely obscure. Here we identify and characterize specific degrada
 tion and sequestration factors\, acting on the ribosome\, when co-translat
 ional protein complex assembly interactions are perturbed. Combing ribosom
 e profiling and ribosome-targeted proteomics approaches\, we discover a no
 vel quality-control pathway for complex subunits that fail to assemble int
 o functional complexes. 
LOCATION:Biology auditorium and by ZOOM:https://technion.zoom.us/j/95921701
 38?omn=99221930350 

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DTSTART:20241027T010000

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