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UID:1277@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250422T130000

DTEND;TZID=Asia/Jerusalem:20250422T140000

DTSTAMP:20250407T135703Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-liron-
 sulimani/

SUMMARY:PhD Graduate Seminar-Liron Sulimani [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title:  Multi-Omics Pro
 filing of Endocannabinoid System Remodeling in Aging Alzheimer’s Disease
  Mice\n\nThe endocannabinoid system (ECS) plays a crucial role in regulati
 ng brain homeostasis\, inflammation\, and aging. In this seminar\, I will 
 present new findings on how the ECS is altered in Alzheimer's disease usin
 g the 5xFAD mouse model across different ages. By combining targeted lipid
 omics of endocannabinoid ligands with quantitative proteomics\, we identif
 ied age- and genotype-dependent changes that point to dysregulation of neu
 roprotective pathways. Notably\, levels of the endocannabinoid-like molecu
 le PEA decreased in parallel with increased expression of its degrading en
 zyme NAAA in 5xFAD mice. These shifts may contribute to enhanced neuroinfl
 ammation and neurodegeneration. Our integrative approach sheds light on th
 e molecular interface between aging\, ECS imbalance\, and Alzheimer’s pa
 thology. These findings open new directions for therapeutic intervention t
 argeting the ECS in neurodegenerative disease 

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TZID:Asia/Jerusalem

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DTSTART:20250328T030000

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