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UID:1344@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20260114T130000

DTEND;TZID=Asia/Jerusalem:20260114T140000

DTSTAMP:20251224T102012Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-malak-
 darawshe/

SUMMARY:PhD Graduate Seminar- Malak Darawshe [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/96635422862  Malak Darawshe\n Affiliation: \n Host:Prof. N
 abieh Ayoub\n LSm4 protein forms RNA degradation hubs at DNA breaks to fac
 ilitate repair\n\nAccurate repair of DNA double-strand breaks (DSBs) is es
 sential for genomic stability\, especially in transcriptionally active reg
 ions. Persistent transcription at DSBs leads to the formation of RNA:DNA h
 ybrids (R-loops)\, which obstruct homologous recombination (HR). While R-l
 oop resolution is understood\, the mechanisms that remove pre-existing RNA
  transcripts in the vicinity of DSBs to limit R-loop formation remain poor
 ly understood. In my PhD\, I describe a mechanism by which cells locally d
 egrade RNA at DSBs to enable repair. I show that the RNA-binding protein L
 Sm4 is rapidly recruited to DSBs in active chromatin\, where it undergoes 
 liquid-liquid phase separation (LLPS) to form biomolecular condensates. Th
 ese condensates function as processing hubs that promote RNA decapping and
  recruit the 5′→3′ exonuclease XRN2 to degrade nascent transcripts n
 ear the break. This LSm4–XRN2 axis suppresses pathological R-loop accumu
 lation\, facilitating RAD51 recruitment and accurate HR. Loss of LSm4 lead
 s to genomic instability and increased translocations. These findings esta
 blish phase-separated condensates as spatial organizers of RNA clearance a
 t DNA lesions\, revealing a new paradigm for coordinating local RNA turnov
 er with faithful DNA repair. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/96635422862

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