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UID:1272@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250317T130000

DTEND;TZID=Asia/Jerusalem:20250317T140000

DTSTAMP:20250310T095133Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-maya-s
 udman/

SUMMARY:PhD Graduate Seminar- Maya Sudman [No Categories]
DESCRIPTION:Location: Biology auditorium and by ZOOM: https://technion.zoom
 .us/j/92240169966  Maya Sudman\n Affiliation: \n Host:Prof. PHILIPPA MELAM
 ED\n The effect of adrenarche on the reproductive axis\n\nAdrenarche is a 
 developmental process almost unique to humans in which the adrenal glands 
 produce high levels of dehydroepiandrosterone (DHEA) ~2-3 years before pub
 erty. Although the function of adrenarche is not known\, premature adrenar
 che often leads to early puberty and polycystic ovarian syndrome (PCOS). W
 e hypothesized that these DHEA effects involve epigenetic modification. We
  examined DNA methylation levels in proxy tissues from a large cohort of c
 hildren\, and found levels around several puberty and PCOS-related genes w
 ere linked to DHEA levels. We then used a novel animal model for adrenarch
 e\, the spiny mouse\, to investigate changes in gene expression in reprodu
 ctive tissues during their natural adrenarche-like state\, and after prepu
 bertal adrenalectomy (ADX) and DHEA rescue. Our findings provide new insig
 hts into how DHEA affects the reproductive axis maturation leading up to p
 uberty\, and at high levels may predispose to PCOS. 
LOCATION:Biology auditorium and by ZOOM: https://technion.zoom.us/j/9224016
 9966

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DTSTART:20241027T010000

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