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UID:1188@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230828T130000

DTEND;TZID=Asia/Jerusalem:20230828T140000

DTSTAMP:20230814T095029Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-miriam
 -fokra/

SUMMARY:PhD Graduate Seminar- Miriam Fokra [No Categories]
DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/9391176471  \n Affiliation: \n Host:Prof. Shlomi Tomer\n &nb
 sp\;\n\nGlycine decarboxylase maintains mitochondrial protein lipoylation 
 to support tumor growth\n\nThe folic acid cycle mediates the transfer of o
 ne-carbon (1C) units to support nucleotide biosynthesis. While the importa
 nce of serine as a mitochondrial and cytosolic donor of folate-mediated 1C
  units in cancer cells has been thoroughly investigated\, a potential role
  of glycine oxidation remains unclear. We developed an approach for quanti
 fying mitochondrial glycine cleavage system (GCS) flux by combining stable
  and radioactive isotope tracing with computational flux decomposition. We
  find high GCS flux in hepatocellular carcinoma (HCC)\, supporting nucleot
 ide biosynthesis. Surprisingly\, other than supplying 1C units\, we found 
 that proper function of GCS is important for maintaining protein lipoylati
 on and mitochondrial activity. Genetic silencing of glycine decarboxylase 
 (GLDC) inhibits the lipoylation and activity of pyruvate dehydrogenase (PD
 H) and impairs tumor growth\, suggesting a novel drug target for HCC.\n\n&
 nbsp\; 
LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /9391176471

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