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UID:1273@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250326T130000

DTEND;TZID=Asia/Jerusalem:20250326T140000

DTSTAMP:20250323T103335Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-mona-k
 abha/

SUMMARY:PhD Graduate Seminar-Mona Kabha [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni
 on.zoom.us/j/95404467857   Mona Kabha\n Affiliation: \n Host:  Dr. Noga Ro
 n-Harel\n T Cell Dysfunction in Aging and Disease\n\nMy research focuses o
 n T cell immunity in two contexts of dysfunction: (1) Inborn errors of imm
 unity\, focusing on CARMIL2 deficiency\, where we identified defective met
 abolic reprogramming and partially restored T cell activation through meta
 bolic supplementation. (2) Age-related immune dysfunction. We used a Chime
 ric Antigen Receptor (CAR) T cell model in mice to investigate how aging a
 ffects immunotherapy. We found that aging reduces CAR T cell production\, 
 shifts their phenotype toward effector memory CD4+ T cells\, and induces 
 non-specific cytotoxicity driven by heightened granzyme B secretion. A sim
 ilar phenotype in young T cells transferred into aged hosts suggests these
  dysfunctions are driven by the aged microenvironment. 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/
 95404467857

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