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UID:1177@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230516T130000

DTEND;TZID=Asia/Jerusalem:20230516T140000

DTSTAMP:20230509T053152Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-nimrod
 -golan/

SUMMARY:PhD Graduate Seminar-Nimrod Golan [No Categories]
DESCRIPTION:Location: Place: Hybrid - In the faculty auditorium and on Zoom
 https://technion.zoom.us/j/91249440287  Nimrod Golan\n Affiliation: \n Ho
 st:Associate Prof. Landau Meytal \n The Dance of the Amyloids: The Intrica
 te Interactions of Pseudomonas aeruginosa Biofilm-Associated Amyloids FapB
  and FapC\n\nIn my study\, I delved into the intricate interactions of Fap
 B and FapC\, the main amyloid proteins involved in stabilizing biofilms fo
 rmed by the opportunistic pathogen Pseudomonas aeruginosa. Biofilm formati
 on is a key factor in the pathogen's virulence and persistence in patients
  with lung disease and other comorbidities. We examined the effects of dif
 ferent environmental conditions on the fibrillation rates\, morphologies\,
  and biophysical properties of FapB and FapC. Our investigation also looke
 d into the stability of these proteins in harsh conditions and explored th
 eir interactions within varying environmental factors. We hypothesized the
  reasons for having two different amyloid proteins in the same system. Add
 itionally\, we identified promising molecules that can inhibit FapC fibril
  formation\, potentially reducing biofilm biomass in P. aeruginosa strains
 . Overall\, this study enhances our understanding of the roles played by F
 apB and FapC in biofilm formation and highlights potential strategies to d
 isrupt P. aeruginosa biofilms. 
LOCATION:Place: Hybrid - In the faculty auditorium and on Zoomhttps://tech
 nion.zoom.us/j/91249440287

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