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UID:1111@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220822T130000

DTEND;TZID=Asia/Jerusalem:20220822T140000

DTSTAMP:20220818T114812Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-ofri-l
 evi/

SUMMARY:PhD Graduate Seminar-Ofri Levi [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Roles of Aminoacyl tRNA 
 synthetases in mRNA regulation\n\nAminoacyl tRNA synthetases (aaRSs) are a
  well-studied family of enzymes with a canonical role in charging tRNA wit
 h specific amino acid. Yet\, these proteins appear to exert non-canonical 
 roles\, including post-transcriptional regulation. We performed a comprehe
 nsive analysis of mRNAs bound by almost all S. cerevisiae cytosolic aaRSs.
  Interestingly\, we revealed that aaRSs preferential association with targ
 et mRNA that contains structure and modification mimicry of their cognate 
 tRNAs. Point mutations that disassemble the anticodon mimic or the modific
 ation sites decrease aaRSs binding and affect the target mRNA translation.
  Together\, our results reveal a novel post-transcriptional regulatory mec
 hanism that exploits structure and modification mimicry to control mRNA tr
 anslation according to tRNA charging demands 

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