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UID:959@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20210608T130000

DTEND;TZID=Asia/Jerusalem:20210608T140000

DTSTAMP:20210802T125905Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-olga-s
 nitser-2/

SUMMARY:PhD Graduate seminar-Olga Snitser [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Community-associated met
 hicillin-resistant Staphylococcusaureus (CA-MRSA) has spread worldwide and
  is threatening public health. Itshallmark is the mecA gene\, whichconfers
  resistance to nearly all β-lactam antibiotics. However\, it is unknownwh
 ether mecA provides additionalselective advantages or disadvantages across
  other chemical environments. In myseminar\, I will present a new competit
 ion-based assay that we’ve developed todetermine the fitness effect of m
 ecA.In the assay\, we compete between differentially fluorescently-labeled
  wild-typeCA-MRSA and a mecA deleted strain in1536-well plates in the pres
 ence of ~57\,000 diverse chemical compounds and cefoxitin\,a β-lactam\, a
 t a sub-inhibitory concentration. Surprisingly\, and in contrast toother r
 esistant mechanisms\, we find that mecAprovides a ubiquitous advantage in 
 diverse chemical environments\, includingantibiotics\, non-antibiotic ther
 apeutic drugs and even natural products andsynthetic compounds. I will sha
 re our findings as well as our insights for themechanism underlying this a
 dvantage. Overall\, our findings suggest a wide basisto explain CA-MRSA re
 markable success and rapid dissemination worldwide. 

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DTSTART:20210326T030000

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