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UID:1214@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240320T130000

DTEND;TZID=Asia/Jerusalem:20240320T140000

DTSTAMP:20240313T095526Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-omer-n
 adel-beja-lab/

SUMMARY:PhD Graduate Seminar- Omer Nadel-Beja Lab [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/91036219148    Omer Nadel\n Affiliation: \n Host:Prof. Oded 
 Beja \n Title: Degradation of photosynthetic antennae by viral auxiliary m
 etabolic proteins\n\n&nbsp\;\n\nAbstract: Cyabophage auxiliary metabolic g
 enes have a direct and substantial effect on oceanic photosynthesis and pr
 imary productivity Cyanophages often carry auxiliary metabolic genes (AMGs
 ) acquired from their cyanobacterial hosts\, believed to redirect host cel
 l metabolism for the phage’s benefit. Building on our previous work\, wh
 ich suggested that some uncultured marine cyanophages encode active NblA p
 roteins responsible for phycobilisome (PBS) degradation in cyanobacteria\,
  we knocked out the nblA gene in a marine cyanophage\, and also constructe
 d a marine cyanobacterial strain overexpressing the viral nblA gene\, to i
 nvestigate the role of NblA in viral fitness. Our study revealed that duri
 ng infection\, cyanophages utilize NblA for targeted PBS degradation. When
  comparing the infection courses of the wildtype (WT) cyanophage and the n
 blA deletion mutant in the host cells\, we observed faster propagation in 
 the WT\, suggesting that the nblA gene significantly enhances infection pr
 ogression. Infections by the WT cyanophage led to more than 50% reduction 
 in cyanobacterial photosynthesis\, compared to those infected by the nblA 
 deletion mutant. Based on metagenomic data\, we conclude that cyanophages 
 carrying such nblA genes are widespread and compose between 35% (in surfac
 e waters) to 65% (in Deep Chlorophyll Maximum depths) of oceanic T7-like c
 yanophages. Our data suggest that cyanophage-encoded AMGs such as nblA hav
 e a direct and substantial effect on oceanic photosynthesis and primary pr
 oductivity. 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /91036219148 

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DTSTART:20231029T010000

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