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UID:1298@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250721T130000

DTEND;TZID=Asia/Jerusalem:20250721T140000

DTSTAMP:20250702T145905Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-peleg-
 ragonis-bachar/

SUMMARY:PhD Graduate Seminar-Peleg Ragonis-Bachar [No Categories]
DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec
 hnion.zoom.us/j/98805522689  Peleg Ragonis-Bachar\n Affiliation: \n Host:A
 ssociate Prof. Meytal Landau\n Towards the Design of Targeted Therapeutics
  based on Microbial and Antimicrobial \n\n&nbsp\;\n\nAmyloids\, long thou
 ght to be defined by their classic cross-β fibril structure\, have recent
 ly revealed a surprising new form: the cross-α architecture built from α
 -helices—shifting our fundamental understanding of protein self-assembly
 . Harnessing cutting-edge computational tools that combine secondary struc
 ture prediction with AI-driven biochemical analysis\, I discovered dozens 
 of novel amyloid-forming peptides\, including unique structural variants w
 ith distinct antimicrobial functions. These findings expose the astonishin
 g structural and functional diversity hidden within amyloids\, challenging
  the traditional dogma that structure dictates pathology. Additionally\, u
 sing sequence-based AI model we were able to correlate between various bio
 chemical property of a sequence to the amyloid structure and function. Ult
 imately\, this work opens new frontiers for precisely targeting pathologic
 al amyloids or designing next-generation antimicrobial agents. 
LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us
 /j/98805522689

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