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UID:1161@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230206T130000

DTEND;TZID=Asia/Jerusalem:20230206T140000

DTSTAMP:20230129T083333Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-rawad-
 hanna/

SUMMARY:PhD Graduate Seminar-Rawad Hanna [No Categories]
DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/92993324901   Rawad Hanna\n Affiliation: \n Host:Dr. Kleifel
 d Oded \n Title: comprehensive terminomic characterization of biological s
 ystems.\n\nSeminar abstract:\n\nProtein termini carry valuable information
  related to protein activity\, localization\, interaction and stability. L
 earning these various properties can be detrimental to the complete unders
 tanding of different biological systems. Characterization of all protein t
 ermini (terminome) by standard proteomic approaches is challenging due to 
 their small amounts in the whole proteome sample. Therefore\, enrichment m
 ethods for the N- and C-termini of proteins have been developed\, and they
  have provided insights that would otherwise be difficult to obtain. Yet\,
  all current enrichment methods have many limitations preventing them from
  revealing the complete terminome. Aiming to in-depth characterization of 
 protein termini and their modifications\, we developed two methods that we
  termed LATE and CAPE as novel N-terminal and C-terminal enrichment method
 s. We deployed our methods in various biological systems. Among our key fi
 ndings was the cross-talk between proteolysis and post-translational Nt-ac
 etylation\, which we identified and characterized in apoptosis. In additio
 n\, we discovered hundreds of novel putative substrates of caspase-3 and h
 ighlighted a putative proteolysis-derived translation inhibition mechanism
 . 
LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /92993324901

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DTSTART:20221030T010000

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