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UID:1294@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250625T130000

DTEND;TZID=Asia/Jerusalem:20250625T140000

DTSTAMP:20250624T061542Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-raz-be
 n-david/

SUMMARY:PhD Graduate Seminar- Raz Ben-David [No Categories]
DESCRIPTION:Location: ZOOM: https://technion.zoom.us/j/95719561465   Raz Be
 n-David\n Affiliation: \n Host:Associate Prof. Shenhav Shemer\n Intermitte
 nt Fasting to Attenuate Age-Related Muscle Atrophy In Aging C57BL/6 Mice:\
 n\nStudy of the Underlying Molecular Mechanisms\n\n&nbsp\;\n\nSarcopenia\,
  the age-related loss of muscle mass and strength\, contributes to frailty
 \, impaired mobility\, and metabolic dysfunction. Traditional intervention
 s\, such as resistance training and increased protein intake\, are not alw
 ays feasible\, leading to investigation into alternative strategies. This 
 study investigated whether intermittent fasting can attenuate age-related 
 atrophy\, with particular focus on the preservation of the dystrophin-glyc
 oprotein complex (DGC) and its associated signaling hub involving plakoglo
 bin and the insulin receptor. Young (3-6 months)\, middle-aged (12-15 and 
 15-18 months)\, and old (18-21 months) male C57BL/6 mice underwent 12-week
  regimens of either time-restricted feeding (TRF\; 8-hour feeding/16-hour 
 fasting)\, alternate-day fasting (ADF\; fasting every other day)\, or ad l
 ibitum (AL) feeding. Outcomes measured included body composition\, muscle 
 mass and function\, glucose metabolism\, anabolic signaling\, muscle histo
 logy\, and fiber-type distribution. 
LOCATION:ZOOM: https://technion.zoom.us/j/95719561465

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